In one study, more than nine out of ten participants with a severe form of leukaemia saw their symptoms completely vanish. Four out of five patients with some other blood cancers responded positively to the treatment and more than half ended up symptom free. Lead scientist Professor Stanley Riddell, from the Fred Hutchinson Cancer Research Center in Seattle, US, said the results were among patients who were projected to have two to five months to live. He said this is extraordinary. This is unprecedented in medicine to be honest, to get response rates in this range in these very advanced patients. The technique involves removing immune cells called T-cells from patients, tagging them with receptor molecules that target cancer and putting them back into the body in an infusion. The targeting molecules, known as chimeric antigen receptors or Cars, came from specially bred genetically engineered mice. Once attached to the T-cells, they reduce the ability of the cancer to shield itself from the body’s natural immune system.
Speaking at the American Association for the Advancement of Science annual meeting in Washington DC, Prof Riddell described the results as a potential paradigm shift in cancer treatment. Much more work was required he said adding that it was not clear how long the symptom-free patients would remain in remission. Prof Riddell hopes to try the therapy on patients suffering from cancers with solid tumours but said they would present challenges. Although the body’s natural immune system is geared to tackle cancer, it is often unable to. Sometimes, the body’s defences cannot recognise cancer cells or they find ingenious ways to mask their identity. In the most promising of Prof Riddell’s studies, around 35 patients with acute lymphoblastic leukaemia were treated with the modified cells. Almost all – 94% – went into complete remission. Being in remission is not the same as saying they are cured, because the symptoms can return.
Here, medics are urging caution. Dr Yvonne Doyle, from Public Health England, said it’s an important breakthrough, in that it’s a new technology that seems to have developed something innovative. However, it is on 30 patients who are at a very advanced stage of a particular cancer. So what we need to know is do this work in a wider situation? The treatment is similar to a technique used with success last year on Layla Richards, a one-year-old girl with ALL, by doctors at Great Ormond Street Hospital, who described the results as staggering A consultant immunologist who treated Layla, Professor Waseem Qasim, told Sky News it was still early days We will have to wait and see how these type of treatments play out for solid cancers such as cancers of the lung or the bowel or the breast and so on The first tranche of investigations and successes I think will be in the blood-type cancers.
West Cancer Center has a new tool in its arsenal with which to treat brain cancer and to, in the cancer treatment center’s description significantly extend the rate of patient survival. The new treatment method being offered is thanks to a portable device called the Optune, an FDA-approved therapy that’s worn like a cap and is designed to send low-intensity electrical fields that are meant to disrupt the way cells divide. It basically sticks to the scalp and sends electric current to generate electrical fields inside the brain, targeted at where a tumor is. When the cancer cells try to divide and grow, says West Cancer Center medical oncologist Dr. Manjari Pandey, that’s when the Optune’s electric fields will disrupt that activity and cause cancer cell death. The reason this is really important is this is the first treatment in a long time that has shown increased survival for patients with newly diagnosed adult Glioblastoma Multiforme, which is the most common cancer of the brain in adults Pandey tells The Daily News.